Intra-axonal injection of biologically active materials.

Effects of acute intra-hippocompal injection of bupropion on active avoidance learning in rats

Introduction: Learning and memory deficits in some diseases are new subjects of research. Bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. This study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. Methods: Adult male ...

Axonal transport of proteins. A new view using in vivo covalent labeling

The injection of [2,3-3H]N-succinimidyl propionate ([3H]N-SP) into the rat sciatic nerve was used to covalently label both intra- and extra-axonal proteins. While extra-axonal proteins (e.g., myelin proteins) remained in the injection site, the intra-axonal proteins were transported in both the anterograde and retrograde directions. The mobile labeled proteins appeared to move by normal axonal ...

Sodium Bismuthate: An Efficient Catalyst for the One-pot Synthesis of Biologically Active Spiro[4H-pyran] Derivativesunder Solvent-free Conditions

An efficient sodium bismuthate (NaBiO3) synthesis of biologically active spiro[4H-pyran]derivatives has been accomplished via one-pot three-condensation of isatin/acenaphthequinone, malononitrile and different reagents including 1,3-dicrbonyl compounds, α-naphthol and 4-hydroxycumarin under solvent-free conditions. The notable advantages of the present procedure are: eco-friendly, environmental...

Expression of Biologically Active Recombinant B-Domain-Deleted Human Factor VIII in Mammalian Cells

Neuronal dynamics and axonal flow. IV. Blockage of intra-axonal enzyme transport by colchicine.

The fact that the nucleated center of the nerve cell is the major source of the macromolecular materials required in the maintenance and function of the whole neuron requires the operation of a steady cellulifugal convection of these supplies into and down the nerve fiber. This proximo-distal traffic has been firmly established, but the mechanisms involved in it are still poorly understood. Bes...